Supplementing maternal diet with milk oligosaccharides and probiotics helps develop the immune system and intestinal flora of offsprings

Abstract Intestinal flora is very important for improving the development of immune system in newborns. Maternal diet during pregnancy and lactation one key factors affecting growth offspring. The objective present study was to examine whether supplementation maternal with milk oligosaccharides Bifidobacterium could influence intestinal neonatal mice. In total, 30 pregnant Institute Cancer Research (ICR) mice were randomly divided into six groups: a control group (basal diet) five intervention groups supplemented different doses 2′‐fucosyllactose [2′‐FL] Bb12 ) period. All female monitored physical health gavage. After delivery, number each litter, any deformity, offspring recorded. spleen, blood, fecal samples 10–12 day‐old collected. results demonstrated that probiotics conferred protective effects against lipopolysaccharide (LPS)‐induced immunosuppression by significantly enhancing organ indexes, splenocyte proliferation, immunoglobulin (immunoglobulin G, A, M) production as well macrophage phagocytosis ( p < .05). abundance Lactobacilli Bifidobacteria feces higher than These findings suggest combination 2′‐FL displayed synergistic interactions between two components promote offsprings improve their microbiota through ingestion.